Studies in vitro on the maturation of erythroblasts in normal and pathological conditions.

During the past few years we have been studying the mechanism of the maturation of erythroblasts by observing the survival in vitro of bone marrow cells. By this means the maturation of erythroblasts of adults and children, both normal and pathological, has been followed in physiological and various experimentally modified conditions. We believe that this method furnishes more accurate information on the maturative activity of normal and pathological bone marrow than morphological studies of biopsy specimens recorded by means of maturation curves or indices.